Velosef Injection 1g 1Vial
Velosef Injection 1g 1Vial
Product Form: Injection
Pack Size: 1Vial
Marketed By: GlaxoSmithKline Pakistan Limited
Generic Category: CEPHALOSPORIN ANTIBIOTIC
Diarrhea, nausea, vomiting, or upset stomach may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Velosef (Cephradine) is a semisynthetic cephalosporin antibiotic; oral dosage forms include capsules containing 250 mg and 500 mg cephradine and cephradine for oral suspension containing, after constitution, 125 mg and 250 mg per 5 mL dose.
When not to use
It is contraindicat for use in patients with cephalosporin or penicillin hypersensitivity.
Pseudomembranous colitis has been reported with the use of cephalosporins (and other broad-spectrum antibiotics); therefore, it is important to consider its diagnosis in patients who develop diarrhea in association with antibiotic use. Treatment with broad-spectrum antibiotics alters the normal flora of the colon and may permit overgrowth of clostridia. Studies indicate a toxin produced by Clostridium difficile is one primary cause of antibiotic-associated colitis. Cholestyramine and colestipol resins have been shown to bind the toxin in vitro. Mild cases of colitis may respond to drug discontinuance alone.
Velosef Dosage and Administration
Adults: For respiratory tract infections (other than lobar pneumonia) and skin and skin structure infections, the usual dose is 250 mg every 6 hours or 500 mg every 12 hours.
For lobar pneumonia, the usual dose is 500 mg every 6 hours or 1 g every 12 hours. For uncomplicated urinary tract infections, the usual dose is 500 mg every 12 hours.
Children: No adequate information is available on the efficacy of b.i.d. regimens in children under nine months of age. The usual dose in children over nine months of age is 25 to 50 mg/kg/day administered in equally divided doses every 6 or 12 hours. For otitis media due to H. influenzae, doses are from 75 to 100 mg/kg/day administered in equally divided doses every 6 or 12 hours, but should not exceed 4 g per day. Dosage for children should not exceed the dosage recommended for adults.
As with antibiotic therapy in general, treatment should continued for a minimum of 48 to 72 hours after the patient becomes asymptomatic or evidence of bacterial eradication has been obtaining. In infections caused by group A beta-hemolytic streptococci, a minimum of 10 days of treatment is recommend to guard against the risk of rheumatic fever or glomerulonephritis.
treatment of chronic
In the treatment of chronic urinary tract infection, frequent bacteriologic and clinical appraisal is necessary during therapy and may be necessary for several months afterward. Persistent infections may require treatment for several weeks. Prolonged intensive therapy is recommende for prostatitis. Doses smaller than those indicate are not recommend
Velosef – Clinical Pharmacology
Velosef (Cephradine) is acid stable.
In vitro studies by an ultracentrifugation technique show that at therapeutic serum antibiotic concentrations, cephradine is minimally bound (8 to 17 percent) to normal serum protein.
Cephradine does not pass across the blood-brain barrier to any appreciable extent.
The presence of food in the gastrointestinal tract delays absorption but does not affect the total amount of cephradine absorbed.
Over 90 percent of the drug is excret unchang in the urine within six hours. Peak urine concentrations are approximately 1600 mcg/mL, 3200 mcg/mL, and 4000 mcg/mL following single doses of 250 mg, 500 mg, and 1 g, respectively.
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