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Getryl Tab 1 MG 2×10’s


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Getryl Tab 1 MG 2×10’s

Getryl Tab 1 MG 2×10’s

Full Prescribing Info
Contents
Description
Action
Oral hypoglycemic agent.
Pharmacology: Mechanism of Action: The primary mechanism of action of glimepiride appears to be dependent on stimulating the release of insulin from functioning pancreatic β-cells.Specific Populations: Renal Insufficiency: A single-dose clinical study of glimepiride showed that glimepiride serum levels decreased as renal function decreased. However, metabolites serum levels (mean AUC values) increased. The apparent terminal t½ for glimepiride did not change, while the half-lives for metabolites increased as renal function decreased. Mean urinary excretion of metabolites as percent of dose, however, decreased.

Indications/Uses
Special Populations: In elderly, debilitated or malnourished patients, or in patients with hepatic insufficiency, the initial dosing, dose increments and maintenance dosage should be conservative to avoid hypoglycemic reactions.
Contraindications
Glimepiride is generally well-tolerated. However, following are the side effects reported during treatment with glimepiride.
Hypoglycemia: The greatest potential risk with all sulfonylureas.
Visual Reactions: There may be temporary visual impairment (eg, changes in accommodation and/or blurred vision) due to the change in blood glucose levels, especially at the start of treatment.
Gastrointestinal Reactions: Occasionally, GI symptoms eg, nausea, vomiting, sensations of pressure or fullness in the epigastrium, abdominal pain and diarrhea may occur.
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